Let's start with the obvious: The White Plague is not Dune. But it is definitely Frank Herbert: provocative, complex, dense, and oddly compelling. And yes, there are epigraphs at the beginning of each chapter.
Instead of a galactic empire 20-some thousand years in the future, we start with Ireland circa 1980. Microbiologist John Roe O'Neill loses his wife and children in a terrorist attack. And later a virus decimates humanity, or rather, half of humanity, as it only affects women. It turns out that O'Neill designed the virus as revenge, intending it to strike Ireland, England, and Libya. Of course, viruses don't respect national boundaries and it becomes a global pandemic.